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advancedatheist comments on Best shot at immortality? - Less Wrong Discussion
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"Mind uploading" makes debatable assumptions about how the mind works. It might have the result of killing you while leaving behind a Siri-like app which tricks living people's theory of mind into thinking that you have survived the upload.
Cryonics, by contrast, falls into the realm of testable neuroscience, as Sebastian Seung argues in his new book:
http://www.box.com/shared/static/pakcq9ffu2fral7r5uvd.png