I have argued somewhat that since the sequences are so badly organized, it's nearly impossible to understand them fully if they're not read in chronological order, and in that regard I think it's downright reprehensible to divide them into somewhat arbitrary "sequence" units, when the whole body of work is so interdependent.
It's been years since I've read some of this, but here are some posts that seem like they stand well on their own:
I haven't read the entire sequences; the p...
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Previous discussion here.