Not necessarily. I've allowed things like that. There isn't anything WRONG with your adventurers ascending to Godhood, if that's what they find fun. I had it happen to the one meta campaign world to the point where there was a pantheon made up of nothing but ascended characters (either from the PC's, or from NPC's who ascended using other methods.) It made a good way of keeping track of things that had been done and so couldn't be done in future games: (Ah, you can't use Celerity, Timestop, and Bloodcasting to get infinite turns, Celerity was turned into a divine power by your earlier character Neo.). However, the game sort of runs out of non-hand wavy content at that point, so you just have to make up things like Carnage Endelphia Over-Deities, Mass Produced Corrupted Paragon Dragons, etc. I even had an official metric: If you can use your powers to beat a single character with a EL of 8 higher (The point at which the chart just flat out says "We aren't giving EXP for this, they shouldn't have been able to do that.") They are ascension worthy. It seemed more fun than saying "No, you can't!" And eventually I just stopped planning things out far in advance because I expected a certain amount of gamebreaking from my players. It's like the mental equivalent of eating cake with a cup of confectioners sugar on top though. Eventually, even the players eventually sort of get sick of the sweetness and move onto something else. Once they played around with Godly power for a bit, they usually got tired of it and we moved on to a new campaign in the meta campaign world. But it does still allow you to say "Remember that time we made our own pantheon of gods who clawed their way up from the bottom using a variety of methods?" Which, as memories go, is a neat one to have.