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Jack comments on Malthusian copying: mass death of unhappy life-loving uploads - Less Wrong Discussion
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'Pain asymbolia' is when people feel pain but it isn't painful: they are aware of the damage but it causes no suffering. (As opposed to conditions like leprosy or diabetes, where the pain nerves are dead, report nothing, and this causes endless health problems.)
We already find it very useful to override pain in the interests of long-term gain or optimization (eg. surgery). Why should we not expect uploads to quickly be engineered to pain asymbolia? Pain which is more like a clock ticking away in the corner of one's eye than a needle through the eye doesn't seem like that bad a problem.
You probably don't even need to do that much re-engineering. The 'suffering' of uploads in a Malthusian existence isn't physical pain, just endless mental drudge work. They could probably just interfere with their emotional experience of time so that they didn't get bored or overwhelmed. See, e.g. Diane Van Deren who became one of the world's top ultra-runners (100-300 mile races) after epilepsy surgery damaged her perception of time.
Interesting; I'd never heard of her before. My closest example was the late Jure Robic