In this video, long about 48:00, Eliezer talks about uploading and about how it wouldn't be murder if his meat body were anesthetized before the upload and killed without regaining consciousness.
It's arguable that it wouldn't be murder, but I'm not clear about why Eliezer would want to do it that way. I've got some guesses about why one might want to not let the meat body wake up (legal and practical complications of a double but diverging identity, the meat version feeling hopelessly envious), but I'm not sure whether either of them apply.
On the other hand, I can think of a couple of reasons for *not* eliminating the meat version-- one is that two Eliezers would presumably be better than one, though I don't have a strong intuition about the optimum number of Eliezers. The other, which I consider to be more salient, is that the meat version is a backup in case the upload isn't as good as hoped.
More generally, what would folks here consider to be good enough evidence that uploading was worth doing?
Once you've uploaded I would expect it to be fairly trivial create as many Eliezers as one likes, all with the advantages of being uploaded. But it isn't implausible that there will be some unique advantage to being meat... it just depends on contingent features of the world in which this happens. Features that no one is going to be able to predict reliably.
I recall once having serious objections to the idea of duplicating but those have disappeared over time. I suspect my copies would empathize with each other and I don't think I would worry about 'becoming the unhappy twin'. Though that might change if owned significant property that one or the other copy wouldn't inherit. The flip side of that coin is that I think I would be alright 'killing myself' if I knew a copy of myself (which only differed in very recent memories) was still alive and kicking. Though the longer the divergence the less okay I would be with it. What I hope might one day be possible is integrating the memories of multiple copies so that I could merge and split repeatedly and not have to miss out on anything.