Benjamin_Todd comments on What are your questions about making a difference? - Less Wrong Discussion
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that's a good one. It's going on the list. We have an upcoming series about happiness and career choice. The first (and one of the upcoming posts) are partially relevant. Drethelin's suggesting a good general strategy. If spending's the problem, you could also consider giving up on altruism in that domain, and making a difference in some other way. This is an example of macrooptimisation