There must be some, and it we'd certainly like to investigate which areas of industry are the most harmful. But in general, it's pretty hard for a career to result in the deaths of 600 people, which is a lower bound for what you could do with $1m (you could also fund SI for 1-2 years...). The most common harmful careers seem to inflict economic damage, and since the average dollar is spent on stuff which produces much less welfare than malaria nets or catastrophic risk research, you have to do a lot of it to outweigh your donations, like maybe 1-2 orders of magnitude more. Of course, doing lots of harm with your career might still be ethically impermissible. There's also some tricky questions regarding the long term compounding benefits of economic growth.