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MixedNuts comments on Rationality, Transhumanism, and Mental Health - Less Wrong Discussion
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I can certainly see that, but I would also hope that if someone is, as the OP claims to be, wanting to be truly rational, possibly the very first point in a list of 'how to be rational' rules would be "Don't buy illegal brain-altering chemicals based solely on a remark made by a total stranger on the internet."
Were someone to not be following that rule already, I suspect any other advice any of us could give them would be useless.
(Incidentally, I'm not one of the people who downvoted that comment. It seems reasonable to at least raise the issue.)
The existence of gwern, of Crazy Meds, and of the subset of the trans community unable to get treatment through official channels suggests that this rule isn't actually all that good.