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Matt_Caulfield comments on Open Thread, December 1-15, 2012 - Less Wrong Discussion
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A couple of days ago, GiveWell updated their top charity picks. AMF is still on top, but GiveDirectly bumped SCI from #2 to #3.
They also (very) tentatively recommend splitting your donation among the three: 70% to AMF, 20% to GiveDirectly, and 10% to SCI. The arguments about this in the blog post and comments are pretty interesting. (But I wouldn't stress too much about it: harder choices matter less).