Of course the important question is not whether it makes sense at the fundamental level of physics. The important question is whether it influences the subjective experience of any being we care about (including ourselves).

Personally, I value not dying, subjectively. "Physical continuity" just seems to be an obvious requirement, and that is why most reasonable people would not step into a cut & paste transporter. But really, it's safe (even if my guts don't seem to trust my brain right now).

On the other hand I value very much being happy and not in pain, for the two describe quite different subjective experiences.