CarlShulman comments on UFAI cannot be the Great Filter - Less Wrong Discussion
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It's the move to eukaryotic life, or "complex cells" that's unique. Multicellularity given eukaryotic status seems easy, but eukaryote status happened only once, and about halfway through the habitable lifetime of the Earth.
Thank you for correcting me on this, it has been some time since I thought of this.
This argument is faulty if there is more than one hard step (and the update is not that strong, although significant, even with one step). See Robin's paper for details.