Vladimir_Nesov comments on Why Politics are Important to Less Wrong... - Less Wrong Discussion
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These examples also only compare things with status quo. Status quo is most likely itself "harm" when compared to many of the alternatives.
There are many more ways to arrange things in a defective manner than an effective one. I'd consider deviations from the status quo to be harmful until proven otherwise.
Or in other words: most mutations are harmful.
(Fixed the wording to better match the intended meaning: "compared to the many alternatives" -> "compared to many of the alternatives".)