and might lose interest for "lower life forms"

Lower life forms (as lower nonlife) forms are always interesting as a source of free enthalpy and from many other aspects.

You, as an advanced civilization have no luxury of ignoring. You have to engage, the "Prime directive" is a bullshit.

And you don't need to wait for a radio signal. You go there (everywhere) on your own initiative, you don't wait to be invited.