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Vaniver comments on [LINK] Soylent crowdfunding - Less Wrong Discussion

7 Post author: Qiaochu_Yuan 21 May 2013 07:09PM

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Comment author: gwern 21 May 2013 08:07:35PM *  37 points [-]

To copy over my earlier G+ comment:

ಠ_ಠ I completely disapprove of this. Soylent is a fun idea, sure, but Rhinehart's asking for $100k to launch a Soylent manufacturing company?! He hasn't even done even the minimal crappy self-experiments he could've done very easily, like randomize weeks on and off Soylent! Nor, AFAIK, has he published any of the results from the early volunteers or anything, really. This is ridiculous.

See also Hacker News

Comment author: huh 22 May 2013 12:28:06AM 11 points [-]

I suspect most people considering Soylent aren't exactly eating like Michael Pollan in the first place. Anecdotally, I know several people who subsist on diets of fast-food takeout washed down by multiple liters of soda. It seems credible that Soylent might at least provide better nutrition than that. The scorn directed at Soylent by many of the Hacker News commenters strikes me as misdirected given the relatively poor quality diet of many Americans.

I have used other commercially available meal replacement shakes in the past - most don't even attempt to deliver complete nutrition beyond covering each of the major macronutrients (protein, carbohydrate, fat). There seems to be room for improvement and innovation in this market.

The guinea pigs for Soylent aren't going to be on a multi-month voyage across the ocean or the antarctic tundra without access to other food. If they do encounter deficiency issues, they can simply reintroduce other foods without suffering catastrophic effects. It takes a special kind of stubborn to really deprive yourself to the point of serious deficiency.

Comment author: Lumifer 22 May 2013 03:30:02PM 2 points [-]

If they do encounter deficiency issues, they can simply reintroduce other foods without suffering catastrophic effects.

And how would they know? Let's say a child develops a iodine deficiency -- a common consequence is the drop in IQ, 10-15 points on the average. You think this will be detected in time to fix this? Let's imagine -- not an improbable scenario at all -- that a deficiency of micronutrient X doubles or triples your risk of some old-age disease Y. By the time you're diagnosed with Y it's way too late to do anything.

Comment author: gwern 22 May 2013 03:47:54PM 5 points [-]

I'd point out that iodine deficiency's effect on IQ seems to be entirely prenatal - that is, there is a window of vulnerability during a human's development, and once they're past that, iodine deficiency no longer operates on IQ (for better or worse) and all that's left are more minor effects like reducing goiters. Seems possible that a lot of nutrients are like that: main effects of deficiency are in childhood/infancy/prenatal.

Comment author: OrphanWilde 22 May 2013 07:40:43PM 2 points [-]

When my iodine levels get low I develop symptoms of diabetes. Sushi can induce insulin shock/hypoglycemia in me.

It screws with my hunger and thirst levels as well.

Apparently I'm not alone, either; there seems to be some evidence that there's a link between iodine and diabetes more generally.

Comment author: J_Taylor 23 May 2013 04:11:35AM *  1 point [-]

Apparently I'm not alone, either; there seems to be some evidence that there's a link between iodine and diabetes more generally.

Could you please post or link to it?

Comment author: OrphanWilde 23 May 2013 02:59:31PM 2 points [-]

See for example https://www.mja.com.au/journal/1999/171/9/iodine-deficiency-ambulatory-participants-sydney-teaching-hospital-australia

and http://link.springer.com/article/10.1007/BF00257427

and http://www.sciencedirect.com/science/article/pii/S1262363607702860

Severe iodine deficiency tends to be much more common in diabetic patients, and hypothyroidism (most commonly caused by iodine deficiency or hashimoto's thyroiditis) tends to be comorbid with diabetes.

Comment author: huh 22 May 2013 05:44:25PM 2 points [-]

By the time you're diagnosed with Y it's way too late to do anything.

OK, that's probably true. It is also true in the case of deficiencies arising from a more conventional diet however. How frequently do micronutrient deficiencies occur under regular diets? How is the chance of timely detection and intervention affected by controlled intake in conjunction with deliberate ongoing monitoring versus an unmonitored ad libitum diet?

Let's consider two contrasting propositions regarding diet and nutrition: A) Consuming a varied diet of naturally occurring, unprocessed foods prevents micronutrient deficiencies. B) Deliberately engineered supplementation prevents micronutrient deficiencies.

Before reading on, take a moment to consider how much confidence you have in proposition A versus B.

Since you introduced the example of iodine deficiency, let's consider it in more depth. The Wikipedia page on iodine deficiency indicates: "According to World Health Organization, in 2007, nearly 2 billion individuals had insufficient iodine intake ..."

Furthermore, this deficiency appears to be common even in wealthy industrialized countries where a wide variety of food is readily available: "In a study of the United Kingdom published in 2011, almost 70% of test subjects were found to be iodine deficient."

The article proceeds to explain that iodine deficiency is addressed by deliberately and artificially introducing supplemental iodine into the food supply.

I'm shocked to learn just how widespread iodine deficiency is among people eating a "normal" diet (I would have guessed less than 10% prevalence). It seems like traditional diets do a startlingly poor job of avoiding this particular deficiency. I'm updating my beliefs in favor of proposition B over A in light of this data.

Comment author: gwern 22 May 2013 06:19:37PM 3 points [-]

I'm shocked to learn just how widespread iodine deficiency is among people eating a "normal" diet (I would have guessed less than 10% prevalence).

The worst part is, a lot of that decline is from people trying to eat 'healthy' - and cut out as much salt as possible. Guess what the main source of iodine for people who can't afford seafood for every meal is? Iodized salt.

(If you want US figures for deficiency, you can find some cites in my iodine page, or simply search for papers related to the long-running NHANES survey which is the main source of evidence.)

Comment author: OrphanWilde 22 May 2013 07:36:22PM 2 points [-]

I got chewed out constantly growing up by -everybody- because of my salt intake.

Guess what happened to my salt cravings when I added an iodine supplement as an adult?

People don't just screw themselves up on that one.

Comment author: Zaine 22 May 2013 12:40:56AM *  1 point [-]

If you're willing to guinea pig, please try this if you haven't already. It's short on macro-nutrients, but perhaps it would pair nicely with macro-nutrient focussed substitutes. I'm interested in comparisons between how these products compare to the actual constituent ingredients consumed normally, but don't value the information enough to try it myself.

Comment author: drethelin 22 May 2013 01:26:54AM -1 points [-]

seems like way too little fat