Run it. There is a non-zero possibility that a paperclips AI could destroy other life which I would care about, and a probability that it would create such life. I would put every effort I could into determining those 2 probabilities (mostly by accumulating the evidence from people much smarter than me, but still). I'll do the action with the highest expected value. If I had no time, though, I'd run it, because I estimate a ridiculously small chance that it would create life relative to destroying everything I could possibly care about.
Thought experiment:
Through whatever accident of history underlies these philosophical dilemmas, you are faced with a choice between two, and only two, mutually exclusive options:
* Choose A, and all life and sapience in the solar system (and presumably the universe), save for a sapient paperclipping AI, dies.
* Choose B, and all life and sapience in the solar system, including the paperclipping AI, dies.
Phrased another way: does the existence of any intelligence at all, even a paperclipper, have even the smallest amount of utility above no intelligence at all?
If anyone responds positively, subsequent questions would be which would be preferred, a paperclipper or a single bacteria; a paperclipper or a self-sustaining population of trilobites and their supporting ecology; a paperclipper or a self-sustaining population of australopithecines; and so forth, until the equivalent value is determined.