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John_D comments on Exercise isn't necessarily good for people - Less Wrong Discussion
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It seems the results show on that some actually get worse, but I wouldn't say this is a firm conclusion that some should avoid exercise altogether. The problem with most experimental studies on exercise is that many use an across-the-board regimen for all participants that isn't customized to the individual. So, if one participant gets 30 mins a day at 70% of HRmax then all do. It is probable that some who get worse may need less or more exercise, greater or lesser intensity, resistance as opposed to aerobic, etc.
This is what came to mind to me too. If you have someone who is thoroughly unhealthy & metabolically broken, adding a bunch of exercise on top of that is not a positive stressor, it is likely to knock them down even further. You have to approach things in order, like fixing the diet & addressing potential issues like hypothyroidism before you start training them to be an athlete.