Possibly relevant paper suggesting there may be at least one genetic modification with the potential to make large improvements in IQ (~25 IQ points)
Most reported associations with intelligence are from underpowered studies and have not replicated in larger samples. That site did not show up in a recent study of 100,000+ people, and generally hasn't been replicated over the last 6 years as sample sizes have exploded.
ETA: Gwern's comment below suggests a relatively plausible explanation for non-replication.
The article by Robert Sparrow:
Quote:
The possibility was discussed in MIRI's "Uncertain Future" toy forecasting model back in 2009, and the analysis formulated a few years before that.
ETA: And further discussed in James Miller's recent book, "Singularity Rising."