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lukeprog comments on Mistakes repository - Less Wrong Discussion
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Not taking the wisdom of nature seriously and, in particular, failing to appreciate the possibility that a considered intervention (e.g. polyphasic sleep) might do more harm than good.
Failing to do all sorts of things that I would have enjoyed merely because they involved some trivial inconvenience.
I've heard a few people say that polyphasic caused them lasting harm. Was that the case for you?
No. I haven't tried polyphasic sleep, which I mentioned merely as an example of the perils of ignoring the "wisdom of nature" heuristic. (I now realize that my wording didn't make this sufficiently clear.)