But why would we even suspect that? We expect that genes encode traits which increase the inclusive genetic fitness because there's a known mechanism which eliminates genes that don't. So we have a situation in which we know that something (the occurrence of a gene) has distant effects but we don't necessarily knowing the intervening causal chain. This is analogous to knowing somebody's goals without understanding their plan, so a careful application of anthropomorphism might help us understand.
I don't know if there's a mechanism that would make us expect neurons to behave in ways that give them lots of neuromodulators or whatever, even if it makes the entire system less effective.
But why would we even suspect that?
Well, the following is highly speculative, but if many neurons die early at an early age, and there is variation within the individual neurons then the neurons that survive to adulthood will be selected for actions that reinforce their own survival. That said, I'd be surprised if there's enough variation in neurons for anything like this to happen.
Dennett:
I hadn't thought about any of this-- I thought the hard problem of brains was that dendrites grow so that neurons aren't arranged in a static map. Apparently that is just one of the hard problems.
He also discusses the question of how much of culture is parasitic, that philosophy has something valuable to offer about free will (I don't know what he has in mind there), the hard question of how people choose who to trust and why they're so bad at it (he thinks people chose their investment advisers more carefully than they chose their pastors, I suspect he's over-optimistic), and a detailed look at Preachers Who Are Not Believers. That last looks intriguing-- part of the situations is that preachers have been taught it's very bad to shake someone else's faith, so there's an added layer of inhibition which keeps preachers doing their usual job even after they're no longer believers themselves.