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Douglas_Knight comments on Polyphasic Sleep Seed Study: Reprise - Less Wrong Discussion

40 Post author: BrienneYudkowsky 21 September 2013 10:29PM

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Comment author: Douglas_Knight 22 September 2013 02:48:18AM 0 points [-]

Has anyone tried orexin-RA-1 for inducing REM?

Comment author: BrienneYudkowsky 22 September 2013 07:54:25PM *  3 points [-]

Not to my knowledge. Have you? Do you know anyone who has? What do you know about it?

Comment author: Douglas_Knight 23 September 2013 02:46:16AM *  1 point [-]

All I know is from a press release from 7 years ago. Googling it produces rumors that it is behind schedule but still going forward.

Added: it seems to have renamed almorexant and failed a phase 3 trial. But there are other orexin antagonists still being pursued.

Comment author: gwern 22 September 2013 07:04:10PM 2 points [-]

Where would one even get an orexin?

Comment author: Douglas_Knight 23 September 2013 02:50:23AM 0 points [-]

dunno. Orexin-RA-1 isn't a type of orexin, but a drug to block it.

Comment author: gwern 23 September 2013 03:20:50AM 0 points [-]

Yes, that's what I meant: where does one even get useful quantities of these drugs which, AFAIK, have not gotten further than the early clinical trials? They're not really something you can just hop onto Silk Road and buy.

Comment author: Douglas_Knight 23 September 2013 03:55:27AM 0 points [-]

More than one orexin-ra has done phase 3 trials. I think that the key to creating a black market is communicating demand.