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Eliezer_Yudkowsky comments on Open Thread, October 7 - October 12, 2013 - Less Wrong Discussion

5 Post author: Thomas 07 October 2013 02:52PM

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Comment author: ephion 08 October 2013 08:24:29PM *  2 points [-]

It doesn't appear to do that.:

In regards to supplementation, oral melatonin supplements at 500mcg over a period of a week in shift workers did not influence basal secretion, as cessation for one day prior to measurements did not show differences when compared to secretion status prior to supplementation.[24] 24-hour melatonin levels in this study, when graphed, essentially overlapped suggesting next to no variance.[24] These results indicating a lack of negative feedback have been replicated with 2mg[25] and 5mg.[26]

Good question! This is definitely an important thing to consider.

Comment author: Eliezer_Yudkowsky 08 October 2013 10:31:47PM 6 points [-]

One week is a trivial amount of time. I've been taking it for years and have had to slowly, steadily increase the dosage.

Comment author: lavalamp 08 October 2013 11:56:09PM 3 points [-]

Do you have any evidence that the cause is not ordinary aging?

Comment author: ephion 08 October 2013 10:39:03PM 1 point [-]

Interesting! If you don't mind sharing, how much were you taking initially, and how much are you taking now?

Comment author: Eliezer_Yudkowsky 08 October 2013 10:41:23PM 6 points [-]

300mcg initially. Currently at 200mcg to trigger sleep onset 6 hours before, 1.2mg timed-release, and a supplementary 300mcg timed-release or 200mcg if I wake up in the middle of the night.

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