Sure-- a full-scale nuclear war that collapsed civilization and technology but didn't actually kill every living human would count.
In terms of less grandiose things, if the actual lived experience of being a human changed dramatically with the the invention of important and novel emotions or social structures, I would consider that a fundamental change. Some argue that this actually happened during the medieval period and that romantic love didn't exist before then, but I'm highly skeptical of this claim for multiple reasons.
What, in a broad sense, does the future look like? We don't know, and while many have historically made predictions, the track record for such predictions is less than impressive. I have noted that there appear to be two main types of view about the future-- the "new future" and the "business-as-usual future." In order to simplify this discussion, let's restrict it only to the coming century-- the period between 2013 and 2113.
The "new future" is, generally speaking, the idea that the coming century is going to be very different from the present; the "business-as-usual future" is, generally speaking, the idea that the coming century is going to be very similar to the present.
Here are some characteristics of the new future:
Here are some characteristics of the business-as-usual future:
Reference class forecasting seems to indicate that the business-as-usual future is quite likely. But as we know, this is far from a textbook case of reference class forecasting, and applying such techniques may not be helpful. What, then, is a good method of establishing what you think the future will look like?