A book about Einstein and Godel claims both of them were able to identify a problem that became suddenly relevant and trackable due to other developments. I think there are certain 'game changers' that reshape discovery space producing low-hanging fruits. But, I do not think these low hanging fruits stay there for long. The possibility of AGI and X-Risks made some of your examples relevant, and they were addressed shortly after those game changers arose. But otherwise, some of your points seem similar to those on the Einstein-Godel book I read.