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ChristianKl comments on [LINK] Will Eating Nuts Save Your Life? - Less Wrong Discussion
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A RCT for nut consumption with a power to pick up an effect like this is probably prohibitively expensive to set up in the current funding enviroment.
here is a RCT that got A LOT of press six months ago. Roughly, the three arms were: (1) give the person a liter of olive oil per week; (2) give the person 30g of nuts per day; (3) nothing. Nuts and oil equally reduced heart attacks, but only olive oil reduced deaths.
If you look at the table of results, the nuts did have a slightly lower all-cause mortality result than the control group (which brings us back to the power issue).
I think financing is the most constraining part of "where it's possible". Drug trials are far more expensive, but easier to finance. Food trials should be cheaper, but more difficult to finance.
Have any researchers tried kickstarter? I think there would be a lot of people who would be willing to pay for this kind of stuff rather than drug research.