Two points of relevance that I see are:
If we care about the nature of morphisms of computations only because of some computations being people, the question is fundamentally what our concept of people refers to, and if it can refer to anything at all.
If we view isomorphic as a kind of extension of our naïve view of equals, we can ask what the appropriate generalisation is when we discover that equals does not correspond to reality and we need a new ontology as in the linked paper.
Actually, I started thinking about computations containing people (in this context) because I was interested in the idea of one computation simulating another, not the other way around. Specifically, I started thinking about this while reading Scott Aaronson's review of Stephen Wolfram's book. In it, he makes a claim something like: the rule 110 cellular automata hasn't been proved to be turing complete because the simulation has an exponential slowdown. I'm not sure if the claim was that strong, but definitely it was claimed later by others that turing co...
I previously posted this question in another discussion, but it didn't get any replies so, since I now have enough karma, I've decided to make it my first "article".
Any takers?