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Ishaan comments on Open Thread for January 17 - 23 2014 - Less Wrong Discussion
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I'm under the impression that taking substances in intense spikes generally causes tolerance to occur more quickly than taking a slow build-up and slow come-down dose. The former profile is also superior for avoiding negative high/crash side effects resulting from rapid ramp-up / come-down.
However, the only actual sources I can find for which this is true relate to insulin, which could easily be a special case, and I'm not really sure where I got this impression. It's filed away in my mind's "conventional wisdom" drawer and I've never questioned it until today. Can anyone who actually knows confirm/deny this?
I've read that short half-life drugs in general build tolerance faster. No idea if it is true. I too would be interested in confirmation or denial of this line of thought and the others you mentioned.
With that being said, my sleep doctor doesn't think stimulants taken infrequently (a few times per week at most) would have significant tolerance effects. I don't mind a crash too much; might just take a nap because of it.
That wouldn't be too bad, but don't stimulant crashes involve more irritability / low affect / lack of focus than they do sleepiness?
In my case, I wouldn't know. I can't say I've ever experienced a crash any time I've taken stimulants.