So editing the genome for wild mice and lab mice would get very different results.
How do you help a nematode mate?
Actually you don't technically help them mate, you just make a strain that can't reproduce via hermaphrodites self-fertilizing. You keep the males from being out-bred that way.
C. elegans has male and hermaphrodite sexes, not male and female. The hermaphrodites self-fertilize slowly to produce a few hundred hermaphrodite offspring, while mating with a male gives them many times as many offspring with half being male. But the lab-bred males are so bad at mating that even if you have a population that's half male, they get massively outbred by the hermaphr...
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