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EGarrett comments on Open Thread for February 11 - 17 - Less Wrong Discussion
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As a poker player, the idea we always batted back and forth was that Expected Value doesn't change over shorter sample sizes, including a single trial. However you may have a risk of ruin or some external factor (like if you're poor and given the option of being handed $1,000,000 or flipping a coin to win $2,000,001).
Barring that, if you're only interested in maximizing your result, you should follow EV. Even in a single trial.