Those approaches risk turning therapy into stabs in the dark by neglecting the details of what is actually going on inside the black box.

Most people who pretend that they know what goes on inside the black box are wrong anyway.

Drug companies would like to predict which components work based on understanding biochemistry but they still have to run expensive trials in which over 90% of the components fail. Furthermore it becomes exponentially more expensive to discover additional drugs in that way.

That said, the idea of preaching blindness that currently haunts medical research is exactly about the virtue of stabing into the dark. If you would see what you are doing you wouldn't be objective anymore.