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Lumifer comments on Open Thread April 16 - April 22, 2014 - Less Wrong Discussion
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If you have a prior, you can.
In a slightly more unrolled manner, if the results you are getting are inconsistent with your ideas of how the world works, one hypothesis that you should update is that your ideas about the world are wrong. But another hypothesis that you should also update is that your sampling method is wrong, e.g. by having a systematic bias.