NancyLebovitz comments on The Cryonics Strategy Space - Less Wrong Discussion
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I don't think it would be possible to know the optimal moment to begin the process, but I think there are a number of diseases where it would be possible to choose a pretty good moment to begin.
I agree... I don't really see why anyone would have problems with their utility functions if they e.g. knew they were going into liver and kidney failure and going to die in the next 24-72 hours.
Not just extreme cases like that, but if you're pretty sure you've got a sort of dementia which is a steady downhill slide.