This is the monthly thread for posting media of various types that you've found that you enjoy. Post what you're reading, listening to, watching, and your opinion of it. Post recommendations to blogs. Post whatever media you feel like discussing! To see previous recommendations, check out the older threads.
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"Preparing for the Possibility of a North Korean Collapse", Bennett 2013 (A fascinating read. I didn't know many of those details about how the East German collapse was able to go so smoothly, or that Kim Jong-Il had intimidated his subordinates during the '90s famines with footage of impoverished humiliated East German elites.)
"Happy birthday, Satoshi Nakamoto" (Satoshi Nakamoto left a cool Easter egg in his profile: his birthdate (5 April 1975) is a double reference to the banning & relegalization of gold in the USA.)
"Do Elephants Have Souls?" ("Another way of catching elephants, employed less now than it used to be, is to save the babies from a cull and market them. Because of the psychological problems caused by having their entire families slaughtered around them, culling experts now recommend just killing the babies with everybody else.")
The comments section of the real-life conspiracies article is the most profoundly disappointing thing I've read in a while.
5[anonymous]
I printed out the original paper and read it with some labmates.
Very interesting. The age marker he has created is a simple linear combination of the methylation ratio of several hundred CpG sites (places that a class of methylating enzymes act upon in animals) from large public datasets. Some are positively correlated with age and some are negatively correlated.
I would be interested in people trying to decompose it into subsets of CpGs that have most of their change over childhood or adolescence versus those that change constantly or change only after adolescence.
It's interesting that muscle tissue and adipose tissue shows very poor correlation while blood and epithelium (two cell types which are constantly proliferating) and brain tissue (very little proliferation at least among the neurons themselves) all show very good correlations. The finding that tumors with few mutations showed major age acceleration while those with many mutations showed less is interesting and provides several possible models of what this could mean.
He proposes a model that methylation age represents the cumulative buildup of the results of an epigenetic maintenance system, but at this early date I would not trust any mechanism Ideas just yet. It leaves open the question if this is a biomarker for a functionally significant epigenetic state, or just a marker for time since cell diffferentiation uncorrelated to other functional differences - though cancer was generally associated with older DNA methylation inferred age in the tissue it arose from suggesting it is at least correlated with something important.
This is the monthly thread for posting media of various types that you've found that you enjoy. Post what you're reading, listening to, watching, and your opinion of it. Post recommendations to blogs. Post whatever media you feel like discussing! To see previous recommendations, check out the older threads.
Rules: