What kind of things override loss of life and and can be widely agreed upon?
In the self-driving car example, say "getting to your destination". Keep in mind that the mere act of the car getting out on the road increases the expected number of resulting deaths.
When a collision is unavoidable, should a self-driving car try to maximize the survival chances of its occupants, or of all people involved?
http://www.wired.com/2014/05/the-robot-car-of-tomorrow-might-just-be-programmed-to-hit-you/