Random methods are employed frequently because to do otherwise would require thought.
There is another more charitable possible justification, sometimes you're using such an approach to solve a problem you genuinely don't know how to solve yourself and clever tricks you use may unwittingly shut off valuable areas of the search space.
One of the most interesting debates on Less Wrong that seems like it should be definitively resolvable is the one between Eliezer Yudkowsky, Scott Aaronson, and others on The Weighted Majority Algorithm. I'll reprint the debate here in case anyone wants to comment further on it.
In that post, Eliezer argues that "noise hath no power" (read the post for details). Scott disagreed. He replied:
Eliezer replied:
Scott replied:
And later added:
Eliezer replied:
Scott replied:
And that's where the debate drops off, at least between Eliezer and Scott, at least on that thread.