I am assign a pretty high likelihood that what we call depression is in fact several distinct disorders that merely present similar symptoms, and that for this reason we are never going to get really effective treatment's for depression until we get better diagnostics. It would explain why people have such varying drug responses - if you have depression type a and get medication effective for depression type d...
I suggested recently that part of the problem with with LW was a lock of discussion posts which was caused by people not thinking of much to post about.
When I ask myself "what might be a good topic for a post?", my mind goes blank, but surely not everything that's worth saying that's related to rationality has been said.
So, is there something at the back of your mind which might be interesting? A topic which got some discussion in an open thread that could be worth pursuing?
If you've found anything which helps you generate useable ideas, please comment about it-- or possibly write a post on the subject.