We just don't know at this point.
Why do you have your skeptical prior? Where have similar genetic engineering efforts failed? Have we not been able to breed cows and cats and dogs and horses for all sorts of things and traits many SDs beyond their ancestral wild populations?
By "very high IQ types" I mean geniuses. MIT, Stanford, etc. do not graduate geniuses, they graduate merely high-IQ people.
If there are large negative effects then you should be able to show it by looking at the available large samples of high-IQ types, of which MIT/Stanford/SMPY/etc are the best ones. There's not going to be any magical triggerpoint where IQ 150 people have all the benefits we know high IQ types do and which all the extrapolations predict and we verify up to the limits of our research capability, and then just beyond where we can gather reliable sample sizes, at IQ 151, suddenly they start to lose 20 years of life expectancy and go mad.
I would expect geniuses to have a higher rate of mental/emotional issues and a shorter lifespan,
It sounds like your beliefs on this topic are molded by some outdated Romantic myths about genius.
I'm talking about different paths.
I have no idea what you mean. All proposals are for using GWAS results based on existing variation (since no one knows what other genetic changes one would make!), and my argument for safety works there. What different paths?
Have we not been able to breed cows and cats and dogs and horses for all sorts of things and traits many SDs beyond their ancestral wild populations?
Not for intelligence, as far as I know. Though dog breeds are widely considered to vary in intelligence -- have there been any attempts to quantify it?
As to "failing", traditional genetic engineering certainly ran into some limits. To continue with dogs, large breeds have shorter lifespans. Many breeds have well-known pervasive genetic problems (hip dysplasia in German shepherds, etc.).
...It sounds
I suggested recently that part of the problem with with LW was a lock of discussion posts which was caused by people not thinking of much to post about.
When I ask myself "what might be a good topic for a post?", my mind goes blank, but surely not everything that's worth saying that's related to rationality has been said.
So, is there something at the back of your mind which might be interesting? A topic which got some discussion in an open thread that could be worth pursuing?
If you've found anything which helps you generate useable ideas, please comment about it-- or possibly write a post on the subject.