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Sean_o_h comments on Rationalist Sport - Less Wrong Discussion
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Some emerging concerns I'm aware of for really serious runners: heart problems due to thickened heart wall, skin cancer (just due to being out in the sun so much, sweating off sunscreen). Potential causes for concern: lots of cortisol production from hard aerobic exercise, inflammation.
I keep wondering whether sports where the major point is overriding the desire to stop are actually a bad idea-- that desire to stop might have evolved to be protective.