Lalartu comments on Quickly passing through the great filter - Less Wrong Discussion
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If "late filter" variant is true, it means interstellar colonization is just impossible, for reasons that can be outside the limits of modern scientific knowledge.
and a reason could include that advanced civilizations destroy themselves with very high probability before they can colonize space.
"Very high probability" of this kind in practice means "always". So either technological progress brings some dangers that just cannot be avoided before building starships is possible, or starships thenselves are not viable.