The official Peter Parker version had Gwen Stacy die on him. I've seen a commentary which pointed out that this directly disproves the mantra about great power and great responsibility, since although Uncle Ben was a case where refusing to be a hero got his loved ones killed, Gwen Stacy was a case where deciding to be a hero got his loved ones killed. If he hadn't been Spider-Man, Gwen would have still been alive.
I'm not familiar with the exact canon of how Gwen died, but I don't think it disproves the idea that "with great power comes great responsibility". It's still your responsibility to make sure people don't get hurt, not just to try to use your powers for good.
In HPMOR, Harry calls it "Heroic Responsibility".
..."You could call it heroic responsibility, maybe," Harry Potter said. "Not like the usual sort. It means that whatever happens, no matter what, it's always your fault. Even if you tell Professor McGonagall, she's no
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