Not only is the original sin fictional evidence; its presupossitions about human nature are worthy of being taken far less seriously than my worst nonsense. The whole "things humans are not meant to know" theme goes too much beyond the necessary caution our flaws demand; it's blatantly misanthropic.
I don't think he's referring to the fruit of knowledge of good and evil, I think he's referring to the doctrine of original sin itself, which he's suggesting caused harm by occupying space in Christian brains.
WARNING: Memetic hazard.
http://www.slate.com/articles/technology/bitwise/2014/07/roko_s_basilisk_the_most_terrifying_thought_experiment_of_all_time.html?wpisrc=obnetwork
Is there anything we should do?