From Toby Ord:

Tool assisted speedruns (TAS) are when people take a game and play it frame by frame, effectively providing super reflexes and forethought, where they can spend a day deciding what to do in the next 1/60th of a second if they wish. There are some very extreme examples of this, showing what can be done if you really play a game perfectly. For example, this video shows how to winSuper Mario Bros 3 in 11 minutes. It shows how different optimal play can be from normal play. In particular, on level 8-1, it gains 90 extra lives by a sequence of amazing jumps.

Other TAS runs get more involved and start exploiting subtle glitches in the game. For example, this page talks about speed running NetHack, using a lot of normal tricks, as well as luck manipulation (exploiting the RNG) and exploiting a dangling pointer bug to rewrite parts of memory.

Though there are limits to what AIs could do with sheer speed, it's interesting that great performance can be achieved with speed alone, that this allows different strategies from usual ones, and that it allows the exploitation of otherwise unexploitable glitches and bugs in the setup.