ChristianKl comments on Astray with the Truth: Logic and Math - Less Wrong Discussion
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Handling mathematical systems in an epistemology is in my idea a topic but not a specific problem. In that topic there are probably a bunch of practical problem but.
Molecular biology is a subject. Predicting protein folding results is a specific problem.
If we look at FAI, writing a bot that performs well in the prisoner dilemma tournaments that are about verifying source code of the other bots is a specific problem.
The are also problems in the daily business of doing science where the scientist has to decide between multiple possible courses of action.