There's no secret sauce here. Just take a lot of samples and run a regression.
Pretend for a second it's a nutrition study and apply your usual scepticism :-) You know quite well that "just run a regression" is, um... rarely that simple.
To give one obvious example, interaction effects are an issue, including interaction between genes and the environment.
Pretend for a second it's a nutrition study and apply your usual scepticism :-) You know quite well that "just run a regression" is, um... rarely that simple.
No, that's the great thing about genetic associations! First, genes don't change over a lifetime, so every association is in effect a longitudinal study where the arrow of time immediately rules out A<-B or reverse causation in which IQ somehow causes particular variants to be overrepresented; that takes out one of the three causal pathways. Then you're left with confounding - but ther...
If it's worth saying, but not worth its own post (even in Discussion), then it goes here.
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