You're going to have to explain what meta-ethical view you hold such that "prefer on reflection given full knowledge and rationality" and "should prefer" are different.
I don't think neuroscience would tell you what you'd prefer on reflection given full knowledge and rationality.
As per a recent comment this thread is meant to voice contrarian opinions, that is anything this community tends not to agree with. Thus I ask you to post your contrarian views and upvote anything you do not agree with based on personal beliefs. Spam and trolling still needs to be downvoted.