ChristianKl comments on What supplements do you take, if any? - Less Wrong Discussion
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"it seems a little odd" should lead to noticing confusion and then updating your view of the world so that the world doesn't seem odd anymore.
Things being odd certainly should lead to updating models, however, unless the models are perfect, things may continue to be odd.
In cases like this your models likely aren't build on peer reviewed research about the behavior of health freaks. Humans are very often overconfident. There no good reason to assume that your model is perfect.