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CellBioGuy comments on November 2014 Media Thread - Less Wrong Discussion
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Deleterious things get locked into fixation in genomes and biological systems all the time. I see no reason that deleterious traits cannot get fixed into cultures.
Oh, they surely can. But that gives those cultures a disadvantage and maintaining this disadvantage "indefinitely" seems to be a stretch, especially given how cultures are malleable and tend to change anyway.
Indefinitely meant more "comparably to a culture lifespan" than "until the heat death of the universe".