How about ending or at least toning down the war on drugs?
In addition to the public choice theory issues that gwern has already described, many of the problems and most of the severe problems of the war on drugs are path-dependent. Just as the mafia didn't disappear at the end of Prohibition, there's no reason to expect gangs to close up shop because drug funding disappears.
The gangs wont, but the addicts will stop committing crimes to support their habit, which will free up lots of police manhours, and just about all alternative forms of crime the core gangs would turn to are different from the drug trade in one key aspect - The victims will generally cooperate with the law when it comes to putting them behind bars. And without addicts doing stupid stuff and getting caught, lots of empty jail cells to throw the gangs in, too.
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