This is not a specific problem caused by Less Wrong users, but I doubt I am the only one to experience it. I found Less Wrong as a young teenager searching for ways to improve herself and understand the world. This site was immensely helpful but it was also immensely isolating. I live in the bible belt, and I have always had few people to talk to. Also due to my age and inexperience there were few contributions I could make to the Less Wrong community. The intelligent level of discussion here contrasted sharply with my school and my friends and I began spending far too much time wanting connections I could not yet have. This contributed to a state of depression I was unable to think my way out of.

Sad as it made me, I actually had to ignore the Less Wrong community for a while so I could get back into equilibrium. I am older now, and on my way to college so I plan to get involved in this community again.

A more concrete example: I attempted to talk to my mother, a doctor, about humans and immortality. She took it as an insinuation that doctors and scientists weren't currently working hard enough and grew very angry.