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skeptical_lurker comments on Brain-centredness and mind uploading - Less Wrong Discussion
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If we care about preserving a "self" and we also believe that someone is still the same person when on drugs or when their hormones are playing up (this is not intended to be sexist, although I suppose it could sound like that) or when they are just really angry, then we shouldn't be too worries about brain chemistry.
I agree. For a very positive spin on transhumanist brain chemistry engineering, I recommend reading http://biopsychiatry.com/
We usually don't worry about personality changes because they're typically quite limited. Completely replacing brain biochemistry would be a change on a completely different scale.
And people occasionally do worry about these changes even now, especially if they're permanent, and if/when they occur in others. Some divorces are made because the partner of a person "does not see the same man/woman she/he fell in love with".