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gedymin comments on Brain-centredness and mind uploading - Less Wrong Discussion
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We usually don't worry about personality changes because they're typically quite limited. Completely replacing brain biochemistry would be a change on a completely different scale.
And people occasionally do worry about these changes even now, especially if they're permanent, and if/when they occur in others. Some divorces are made because the partner of a person "does not see the same man/woman she/he fell in love with".